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KMID : 1144120220120030303
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Biomedical Engineering Letters
2022 Volume.12 No. 3 p.303 ~ p.316
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Deep brain stimulation for Parkinson’s Disease: A Review and Future Outlook
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Malvea Anahita
Babaei Farbod
Boulay Chadwick
Sachs Adam
Park Jeong-Won
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Abstract
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Parkinson’s Disease (PD) is a neurodegenerative disorder that manifests as an impairment of motor and non-motor abilities due to a loss of dopamine input to deep brain structures. While there is presently no cure for PD, a variety of pharmacological and surgical therapeutic interventions have been developed to manage PD symptoms. This review explores the past, present and future outlooks of PD treatment, with particular attention paid to deep brain stimulation (DBS), the surgical procedure to deliver DBS, and its limitations. Finally, our group’s efforts with respect to brain mapping for DBS targeting will be discussed.
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KEYWORD
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Parkinson’s disease (PD), Parkinson’s symptoms, Deep brain stimulation (DBS), Essential tremor, Dystonia, Bradykinesia, Treatment resistant depression (TRD), Alzheimer’s, Tourette syndrome (TS), Subthalamic nucleus (STN), Thalamus (VM), globus pallidus interna (GPi)
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